Some Properties of a Cardioactive Substance Isolated from Human Plasma.
نویسندگان
چکیده
• The beneficial effect of plasma on isolated saline-perfused frog hearts, first described by Ringer in 1883 and confirmed by Clark in 1913, has led to widespread interest in the isolation of naturally-occurring positively inotropic substances from plasma and other body tissues."" The isolation from mammalian plasma of a protein system which increases the contractile force of isolated frog hearts was described recently by Hajdu and Leonard. This protein system consists of three globulins, designated cardioglobulin A, B, and C by them, the simultaneous presence of all three globulins being apparently necessary for the maintenance of inotropic activity. Leonard and Hajdu associated certain types of cardiovascular abnormalities with variations in the activity of the plasma cardioglobulins. The effect of plasma on the contractile activity of hearts isolated from a variety of poikilothermic animals other than frogs was investigated and described by Nayler and McCulloch who showed that the augmented contractions which followed the addition of plasma to perfused isolated toad hearts were associated with improved mechanical efficiency. Curtain and Nayler isolated from human plasma a substance which evokes a positive inotropic response in perfused isolated hearts of toads (Bufo marinus) and which has a molecular weight of only 4000 to 8000.
منابع مشابه
G1 Phase Arrest and Apoptosis Induction in Human Thyroid Cancer Cell Line Thr.C1.PI33 by 3-Hydrogenkwadaphnin Isolated from Dendrostellera lessertii
Dendrostellera lessertii (Thymelaeaceae) is a toxic plant that grows in parts of Iran. The anti-proliferative properties of its crude methanol extract and one of its active components, 3-hydrogenkwadaphnin (3-HK), have been established using several cancer cell lines. Methods: In a further attempt to determine the mode of action, two groups of synchronously growing cells were treated with a sin...
متن کاملSome effects of a cardioactive fraction isolated from human blood plasma on the peripheral circulation of the dog.
متن کامل
انتقال ژن‌های بیماری‌زایی و مقاومت آنتی‌بیوتیکی در گونه‌های انتروکوک از طریق کانجوگاسیون
Background & Aim: Enterococci comprise an important and diverse group of bacteria that cause disease in human and animals. They reside in the gastrointestinal tract of human and animal, soil, water, foods, and can persist in elevated salt contents and various pH values. They can readily acquire antibiotic resistance and various other virulence factors. In this study, the prevalence of vario...
متن کاملEffects of liver fractions on myocardial contractility.
EVER since the early experiments of Ringer, it has been known that isolated heart muscle contracts more forcefully and for a longer time in serum than in an artificial medium. Evidence implicating the liver as a source of such a humoral factor has been reviewed. In the search for the active compound^) in liver, an impure extract was shown to mimic the effect of serum on myocardial contractility...
متن کاملIn vitro Assessment of Some Probiotic Properties of Lactobacillus fermentum Isolated from Pickled Garlic
Background: Dominant Lactic Acid Bacteria (LAB) originally isolated from traditional non-dairy fermented foods, may harbor unique characteristics such as probiotic properties. In this research, probiotic potential of dominant LAB isolated from pickled garlic was studied. Methods: After isolation of dominant LAB from pickled garlic produced with apple cider vinegar, the isolate was identified...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Circulation research
دوره 16 شماره
صفحات -
تاریخ انتشار 1965